Canagliflozin vs Metformin

Canagliflozin vs Metformin: Overview

This comparison examines the pharmacological differences between Canagliflozin and Metformin.

Mechanism of Action

Canagliflozin: Selective SGLT2 inhibitor reducing renal glucose reabsorption and lowering blood glucose.

Metformin: Activates AMP-activated protein kinase, decreasing hepatic glucose production.

Pharmacokinetics

Half-life: Canagliflozin — 10.6 hours; Metformin — 4-9 hours.

Chemical Properties

Molecular Formula: Canagliflozin — C24H25FO5S; Metformin — C4H11N5.

Molecular Weight: Canagliflozin — 444.5170 g/mol; Metformin — 129.1640 g/mol.

Type: Canagliflozin — Small molecule; Metformin — Small molecule.