Candesartan vs Captopril

Candesartan vs Captopril: Overview

This comparison examines the pharmacological differences between Candesartan and Captopril.

Mechanism of Action

Candesartan: Prodrug hydrolyzed to active form; selective angiotensin II type 1 receptor blocker.

Captopril: First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

Pharmacokinetics

Half-life: Candesartan — 9 hours; Captopril — 1.9 hours.

Chemical Properties

Molecular Formula: Candesartan — C33H34N6O6; Captopril — C9H15NO3S.

Molecular Weight: Candesartan — 610.6640 g/mol; Captopril — 217.2850 g/mol.

Type: Candesartan — Small molecule; Captopril — Small molecule.