Candesartan vs Hydrochlorothiazide

## Candesartan vs Hydrochlorothiazide: Overview

This comparison examines the pharmacological differences between **Candesartan** and **Hydrochlorothiazide**.

## Mechanism of Action

**Candesartan**: Prodrug hydrolyzed to active form; selective angiotensin II type 1 receptor blocker.

**Hydrochlorothiazide**: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

## Pharmacokinetics

**Half-life**: Candesartan — 9 hours; Hydrochlorothiazide — 6-15 hours.

## Chemical Properties

**Molecular Formula**: Candesartan — C33H34N6O6; Hydrochlorothiazide — C7H8ClN3O4S2.

**Molecular Weight**: Candesartan — 610.6640 g/mol; Hydrochlorothiazide — 297.7400 g/mol.

**Type**: Candesartan — Small molecule; Hydrochlorothiazide — Small molecule.