Candesartan vs Hydrochlorothiazide

Candesartan vs Hydrochlorothiazide: Overview

This comparison examines the pharmacological differences between Candesartan and Hydrochlorothiazide.

Mechanism of Action

Candesartan: Prodrug hydrolyzed to active form; selective angiotensin II type 1 receptor blocker.

Hydrochlorothiazide: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

Pharmacokinetics

Half-life: Candesartan — 9 hours; Hydrochlorothiazide — 6-15 hours.

Chemical Properties

Molecular Formula: Candesartan — C33H34N6O6; Hydrochlorothiazide — C7H8ClN3O4S2.

Molecular Weight: Candesartan — 610.6640 g/mol; Hydrochlorothiazide — 297.7400 g/mol.

Type: Candesartan — Small molecule; Hydrochlorothiazide — Small molecule.