Captopril vs Duloxetine

Captopril vs Duloxetine: Overview

This comparison examines the pharmacological differences between Captopril and Duloxetine.

Mechanism of Action

Captopril: First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

Duloxetine: Serotonin-norepinephrine reuptake inhibitor (SNRI).

Pharmacokinetics

Half-life: Captopril — 1.9 hours; Duloxetine — 12 hours.

Chemical Properties

Molecular Formula: Captopril — C9H15NO3S; Duloxetine — C18H19NOS.

Molecular Weight: Captopril — 217.2850 g/mol; Duloxetine — 297.4150 g/mol.

Type: Captopril — Small molecule; Duloxetine — Small molecule.