Captopril vs Hydrochlorothiazide

Captopril vs Hydrochlorothiazide: Overview

This comparison examines the pharmacological differences between Captopril and Hydrochlorothiazide.

Mechanism of Action

Captopril: First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

Hydrochlorothiazide: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

Pharmacokinetics

Half-life: Captopril — 1.9 hours; Hydrochlorothiazide — 6-15 hours.

Chemical Properties

Molecular Formula: Captopril — C9H15NO3S; Hydrochlorothiazide — C7H8ClN3O4S2.

Molecular Weight: Captopril — 217.2850 g/mol; Hydrochlorothiazide — 297.7400 g/mol.

Type: Captopril — Small molecule; Hydrochlorothiazide — Small molecule.