Captopril vs Losartan

Captopril vs Losartan: Overview

This comparison examines the pharmacological differences between Captopril and Losartan.

Mechanism of Action

Captopril: First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

Losartan: Angiotensin II receptor type 1 antagonist.

Pharmacokinetics

Half-life: Captopril — 1.9 hours; Losartan — 2 hours.

Chemical Properties

Molecular Formula: Captopril — C9H15NO3S; Losartan — C22H23ClN6O.

Molecular Weight: Captopril — 217.2850 g/mol; Losartan — 422.9200 g/mol.

Type: Captopril — Small molecule; Losartan — Small molecule.