Captopril vs Ramipril

Captopril vs Ramipril: Overview

This comparison examines the pharmacological differences between Captopril and Ramipril.

Mechanism of Action

Captopril: First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

Ramipril: Prodrug converted to ramiprilat; ACE inhibitor.

Pharmacokinetics

Half-life: Captopril — 1.9 hours; Ramipril — 13-17 hours.

Chemical Properties

Molecular Formula: Captopril — C9H15NO3S; Ramipril — C23H32N2O5.

Molecular Weight: Captopril — 217.2850 g/mol; Ramipril — 416.5120 g/mol.

Type: Captopril — Small molecule; Ramipril — Small molecule.