Captopril vs Sildenafil

## Captopril vs Sildenafil: Overview

This comparison examines the pharmacological differences between **Captopril** and **Sildenafil**.

## Mechanism of Action

**Captopril**: First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

**Sildenafil**: Selective PDE5 inhibitor increasing cGMP.

## Pharmacokinetics

**Half-life**: Captopril — 1.9 hours; Sildenafil — 4 hours.

## Chemical Properties

**Molecular Formula**: Captopril — C9H15NO3S; Sildenafil — C22H30N6O4S.

**Molecular Weight**: Captopril — 217.2850 g/mol; Sildenafil — 474.5800 g/mol.

**Type**: Captopril — Small molecule; Sildenafil — Small molecule.