Captopril vs Spironolactone

Captopril vs Spironolactone: Overview

This comparison examines the pharmacological differences between Captopril and Spironolactone.

Mechanism of Action

Captopril: First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

Spironolactone: Mineralocorticoid receptor antagonist.

Pharmacokinetics

Half-life: Captopril — 1.9 hours; Spironolactone — 1.4 hours.

Chemical Properties

Molecular Formula: Captopril — C9H15NO3S; Spironolactone — C24H32O4S.

Molecular Weight: Captopril — 217.2850 g/mol; Spironolactone — 416.5740 g/mol.

Type: Captopril — Small molecule; Spironolactone — Small molecule.