Captopril vs Trimethoprim

Captopril vs Trimethoprim: Overview

This comparison examines the pharmacological differences between Captopril and Trimethoprim.

Mechanism of Action

Captopril: First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

Trimethoprim: Dihydrofolate reductase inhibitor (bacterial selective).

Pharmacokinetics

Half-life: Captopril — 1.9 hours; Trimethoprim — 8-10 hours.

Chemical Properties

Molecular Formula: Captopril — C9H15NO3S; Trimethoprim — C14H18N4O3.

Molecular Weight: Captopril — 217.2850 g/mol; Trimethoprim — 290.3180 g/mol.

Type: Captopril — Small molecule; Trimethoprim — Small molecule.