Celecoxib vs Tofacitinib

Celecoxib vs Tofacitinib: Overview

This comparison examines the pharmacological differences between Celecoxib and Tofacitinib.

Mechanism of Action

Celecoxib: Selective COX-2 inhibitor.

Tofacitinib: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

Pharmacokinetics

Half-life: Celecoxib — 11 hours; Tofacitinib — 3.2 hours.

Chemical Properties

Molecular Formula: Celecoxib — C17H14F3N3O2S; Tofacitinib — C16H20N6O.

Molecular Weight: Celecoxib — 381.3730 g/mol; Tofacitinib — 312.3700 g/mol.

Type: Celecoxib — Small molecule; Tofacitinib — Small molecule.