Citalopram vs Sertraline

Citalopram vs Sertraline: Overview

This comparison examines the pharmacological differences between Citalopram and Sertraline.

Mechanism of Action

Citalopram: Selective serotonin reuptake inhibitor (SSRI); racemic mixture with escitalopram as active S-enantiomer.

Sertraline: Selective serotonin reuptake inhibitor (SSRI).

Pharmacokinetics

Half-life: Citalopram — 35 hours; Sertraline — 26 hours.

Chemical Properties

Molecular Formula: Citalopram — C20H21FN2O; Sertraline — C17H17Cl2N.

Molecular Weight: Citalopram — 324.3920 g/mol; Sertraline — 306.2290 g/mol.

Type: Citalopram — Small molecule; Sertraline — Small molecule.