Cyclosporine vs Tofacitinib

## Cyclosporine vs Tofacitinib: Overview

This comparison examines the pharmacological differences between **Cyclosporine** and **Tofacitinib**.

## Mechanism of Action

**Cyclosporine**: Calcineurin inhibitor suppressing T-cell activation.

**Tofacitinib**: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

## Pharmacokinetics

**Half-life**: Cyclosporine — 6-12 hours; Tofacitinib — 3.2 hours.

## Chemical Properties

**Molecular Formula**: Cyclosporine — C62H111N11O12; Tofacitinib — C16H20N6O.

**Molecular Weight**: Cyclosporine — 1202.6100 g/mol; Tofacitinib — 312.3700 g/mol.

**Type**: Cyclosporine — Protein; Tofacitinib — Small molecule.