Cyclosporine vs Tofacitinib

Cyclosporine vs Tofacitinib: Overview

This comparison examines the pharmacological differences between Cyclosporine and Tofacitinib.

Mechanism of Action

Cyclosporine: Calcineurin inhibitor suppressing T-cell activation.

Tofacitinib: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

Pharmacokinetics

Half-life: Cyclosporine — 6-12 hours; Tofacitinib — 3.2 hours.

Chemical Properties

Molecular Formula: Cyclosporine — C62H111N11O12; Tofacitinib — C16H20N6O.

Molecular Weight: Cyclosporine — 1202.6100 g/mol; Tofacitinib — 312.3700 g/mol.

Type: Cyclosporine — Protein; Tofacitinib — Small molecule.