Dapagliflozin vs Metformin

Dapagliflozin vs Metformin: Overview

This comparison examines the pharmacological differences between Dapagliflozin and Metformin.

Mechanism of Action

Dapagliflozin: Selective SGLT2 inhibitor reducing renal glucose and sodium reabsorption.

Metformin: Activates AMP-activated protein kinase, decreasing hepatic glucose production.

Pharmacokinetics

Half-life: Dapagliflozin — 12.9 hours; Metformin — 4-9 hours.

Chemical Properties

Molecular Formula: Dapagliflozin — C21H25ClO6; Metformin — C4H11N5.

Molecular Weight: Dapagliflozin — 408.8730 g/mol; Metformin — 129.1640 g/mol.

Type: Dapagliflozin — Small molecule; Metformin — Small molecule.