Diazepam vs Midazolam

## Diazepam vs Midazolam: Overview

This comparison examines the pharmacological differences between **Diazepam** and **Midazolam**.

## Mechanism of Action

**Diazepam**: Positive allosteric modulator of GABA-A receptors.

**Midazolam**: Ultra-short-acting benzodiazepine GABA-A receptor positive allosteric modulator.

## Pharmacokinetics

**Half-life**: Diazepam — 20-100 hours; Midazolam — 1.5-2.5 hours.

## Chemical Properties

**Molecular Formula**: Diazepam — C16H13ClN2O; Midazolam — C18H13ClFN3.

**Molecular Weight**: Diazepam — 284.7400 g/mol; Midazolam — 325.7670 g/mol.

**Type**: Diazepam — Small molecule; Midazolam — Small molecule.