Diazepam vs Midazolam

Diazepam vs Midazolam: Overview

This comparison examines the pharmacological differences between Diazepam and Midazolam.

Mechanism of Action

Diazepam: Positive allosteric modulator of GABA-A receptors.

Midazolam: Ultra-short-acting benzodiazepine GABA-A receptor positive allosteric modulator.

Pharmacokinetics

Half-life: Diazepam — 20-100 hours; Midazolam — 1.5-2.5 hours.

Chemical Properties

Molecular Formula: Diazepam — C16H13ClN2O; Midazolam — C18H13ClFN3.

Molecular Weight: Diazepam — 284.7400 g/mol; Midazolam — 325.7670 g/mol.

Type: Diazepam — Small molecule; Midazolam — Small molecule.