Digoxin vs Tofacitinib

Digoxin vs Tofacitinib: Overview

This comparison examines the pharmacological differences between Digoxin and Tofacitinib.

Mechanism of Action

Digoxin: Inhibits Na+/K+-ATPase, increasing intracellular calcium.

Tofacitinib: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

Pharmacokinetics

Half-life: Digoxin — 36-48 hours; Tofacitinib — 3.2 hours.

Chemical Properties

Molecular Formula: Digoxin — C41H64O14; Tofacitinib — C16H20N6O.

Molecular Weight: Digoxin — 780.9430 g/mol; Tofacitinib — 312.3700 g/mol.

Type: Digoxin — Small molecule; Tofacitinib — Small molecule.