Diltiazem vs Hydrochlorothiazide
Diltiazem vs Hydrochlorothiazide: Overview
This comparison examines the pharmacological differences between Diltiazem and Hydrochlorothiazide.
Mechanism of Action
Diltiazem: Benzothiazepine calcium channel blocker.
Hydrochlorothiazide: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.
Pharmacokinetics
Half-life: Diltiazem — 3-4.5 hours; Hydrochlorothiazide — 6-15 hours.
Chemical Properties
Molecular Formula: Diltiazem — C22H26N2O4S; Hydrochlorothiazide — C7H8ClN3O4S2.
Molecular Weight: Diltiazem — 414.5190 g/mol; Hydrochlorothiazide — 297.7400 g/mol.
Type: Diltiazem — Small molecule; Hydrochlorothiazide — Small molecule.