Diphenhydramine vs Sertraline

## Diphenhydramine vs Sertraline: Overview

This comparison examines the pharmacological differences between **Diphenhydramine** and **Sertraline**.

## Mechanism of Action

**Diphenhydramine**: First-generation H1 antihistamine with anticholinergic properties.

**Sertraline**: Selective serotonin reuptake inhibitor (SSRI).

## Pharmacokinetics

**Half-life**: Diphenhydramine — 2-8 hours; Sertraline — 26 hours.

## Chemical Properties

**Molecular Formula**: Diphenhydramine — C17H21NO; Sertraline — C17H17Cl2N.

**Molecular Weight**: Diphenhydramine — 255.3550 g/mol; Sertraline — 306.2290 g/mol.

**Type**: Diphenhydramine — Small molecule; Sertraline — Small molecule.