Duloxetine vs Fluoxetine

Duloxetine vs Fluoxetine: Overview

This comparison examines the pharmacological differences between Duloxetine and Fluoxetine.

Mechanism of Action

Duloxetine: Serotonin-norepinephrine reuptake inhibitor (SNRI).

Fluoxetine: Selective serotonin reuptake inhibitor (SSRI).

Pharmacokinetics

Half-life: Duloxetine — 12 hours; Fluoxetine — 1-3 days.

Chemical Properties

Molecular Formula: Duloxetine — C18H19NOS; Fluoxetine — C17H18F3NO.

Molecular Weight: Duloxetine — 297.4150 g/mol; Fluoxetine — 309.3260 g/mol.

Type: Duloxetine — Small molecule; Fluoxetine — Small molecule.