Duloxetine vs Methotrexate

## Duloxetine vs Methotrexate: Overview

This comparison examines the pharmacological differences between **Duloxetine** and **Methotrexate**.

## Mechanism of Action

**Duloxetine**: Serotonin-norepinephrine reuptake inhibitor (SNRI).

**Methotrexate**: Dihydrofolate reductase inhibitor.

## Pharmacokinetics

**Half-life**: Duloxetine — 12 hours; Methotrexate — 3-10 hours.

## Chemical Properties

**Molecular Formula**: Duloxetine — C18H19NOS; Methotrexate — C20H22N8O5.

**Molecular Weight**: Duloxetine — 297.4150 g/mol; Methotrexate — 454.4400 g/mol.

**Type**: Duloxetine — Small molecule; Methotrexate — Small molecule.