Duloxetine vs Paroxetine

Duloxetine vs Paroxetine: Overview

This comparison examines the pharmacological differences between Duloxetine and Paroxetine.

Mechanism of Action

Duloxetine: Serotonin-norepinephrine reuptake inhibitor (SNRI).

Paroxetine: Potent selective serotonin reuptake inhibitor with additional muscarinic and NE reuptake inhibition.

Pharmacokinetics

Half-life: Duloxetine — 12 hours; Paroxetine — 21 hours.

Chemical Properties

Molecular Formula: Duloxetine — C18H19NOS; Paroxetine — C19H20FNO3.

Molecular Weight: Duloxetine — 297.4150 g/mol; Paroxetine — 329.3730 g/mol.

Type: Duloxetine — Small molecule; Paroxetine — Small molecule.