Enalapril vs Hydrochlorothiazide

Enalapril vs Hydrochlorothiazide: Overview

This comparison examines the pharmacological differences between Enalapril and Hydrochlorothiazide.

Mechanism of Action

Enalapril: Prodrug converted to enalaprilat; inhibits ACE preventing angiotensin I to II conversion.

Hydrochlorothiazide: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

Pharmacokinetics

Half-life: Enalapril — 11 hours; Hydrochlorothiazide — 6-15 hours.

Chemical Properties

Molecular Formula: Enalapril — C20H28N2O5; Hydrochlorothiazide — C7H8ClN3O4S2.

Molecular Weight: Enalapril — 376.4470 g/mol; Hydrochlorothiazide — 297.7400 g/mol.

Type: Enalapril — Small molecule; Hydrochlorothiazide — Small molecule.