Enalapril vs Irbesartan

Enalapril vs Irbesartan: Overview

This comparison examines the pharmacological differences between Enalapril and Irbesartan.

Mechanism of Action

Enalapril: Prodrug converted to enalaprilat; inhibits ACE preventing angiotensin I to II conversion.

Irbesartan: Selective non-competitive angiotensin II type 1 receptor antagonist.

Pharmacokinetics

Half-life: Enalapril — 11 hours; Irbesartan — 11-15 hours.

Chemical Properties

Molecular Formula: Enalapril — C20H28N2O5; Irbesartan — C25H28N6O.

Molecular Weight: Enalapril — 376.4470 g/mol; Irbesartan — 428.5320 g/mol.

Type: Enalapril — Small molecule; Irbesartan — Small molecule.