Enalapril vs Losartan

Enalapril vs Losartan: Overview

This comparison examines the pharmacological differences between Enalapril and Losartan.

Mechanism of Action

Enalapril: Prodrug converted to enalaprilat; inhibits ACE preventing angiotensin I to II conversion.

Losartan: Angiotensin II receptor type 1 antagonist.

Pharmacokinetics

Half-life: Enalapril — 11 hours; Losartan — 2 hours.

Chemical Properties

Molecular Formula: Enalapril — C20H28N2O5; Losartan — C22H23ClN6O.

Molecular Weight: Enalapril — 376.4470 g/mol; Losartan — 422.9200 g/mol.

Type: Enalapril — Small molecule; Losartan — Small molecule.