Enalapril vs Sacubitril-Valsartan

Enalapril vs Sacubitril-Valsartan: Overview

This comparison examines the pharmacological differences between Enalapril and Sacubitril-Valsartan.

Mechanism of Action

Enalapril: Prodrug converted to enalaprilat; inhibits ACE preventing angiotensin I to II conversion.

Sacubitril-Valsartan: Angiotensin receptor-neprilysin inhibitor (ARNI) combining neprilysin inhibition with AT1 receptor blockade.

Pharmacokinetics

Half-life: Enalapril — 11 hours; Sacubitril-Valsartan — 11.5 hours.

Chemical Properties

Molecular Formula: Enalapril — C20H28N2O5; Sacubitril-Valsartan — C24H29N2O5.

Molecular Weight: Enalapril — 376.4470 g/mol; Sacubitril-Valsartan — 414.5010 g/mol.

Type: Enalapril — Small molecule; Sacubitril-Valsartan — Small molecule.