Enalapril vs Sacubitril-Valsartan

## Enalapril vs Sacubitril-Valsartan: Overview

This comparison examines the pharmacological differences between **Enalapril** and **Sacubitril-Valsartan**.

## Mechanism of Action

**Enalapril**: Prodrug converted to enalaprilat; inhibits ACE preventing angiotensin I to II conversion.

**Sacubitril-Valsartan**: Angiotensin receptor-neprilysin inhibitor (ARNI) combining neprilysin inhibition with AT1 receptor blockade.

## Pharmacokinetics

**Half-life**: Enalapril — 11 hours; Sacubitril-Valsartan — 11.5 hours.

## Chemical Properties

**Molecular Formula**: Enalapril — C20H28N2O5; Sacubitril-Valsartan — C24H29N2O5.

**Molecular Weight**: Enalapril — 376.4470 g/mol; Sacubitril-Valsartan — 414.5010 g/mol.

**Type**: Enalapril — Small molecule; Sacubitril-Valsartan — Small molecule.