Fentanyl vs Morphine

Fentanyl vs Morphine: Overview

This comparison examines the pharmacological differences between Fentanyl and Morphine.

Mechanism of Action

Fentanyl: Highly potent synthetic mu-opioid receptor agonist approximately 100 times more potent than morphine.

Morphine: Mu-opioid receptor agonist.

Pharmacokinetics

Half-life: Fentanyl — 2-4 hours; Morphine — 2-3 hours.

Chemical Properties

Molecular Formula: Fentanyl — C22H28N2O; Morphine — C17H19NO3.

Molecular Weight: Fentanyl — 336.4700 g/mol; Morphine — 285.3380 g/mol.

Type: Fentanyl — Small molecule; Morphine — Small molecule.