Fentanyl vs Tramadol

Fentanyl vs Tramadol: Overview

This comparison examines the pharmacological differences between Fentanyl and Tramadol.

Mechanism of Action

Fentanyl: Highly potent synthetic mu-opioid receptor agonist approximately 100 times more potent than morphine.

Tramadol: Mu-opioid receptor agonist and serotonin-norepinephrine reuptake inhibitor.

Pharmacokinetics

Half-life: Fentanyl — 2-4 hours; Tramadol — 5-7 hours.

Chemical Properties

Molecular Formula: Fentanyl — C22H28N2O; Tramadol — C16H25NO2.

Molecular Weight: Fentanyl — 336.4700 g/mol; Tramadol — 263.3750 g/mol.

Type: Fentanyl — Small molecule; Tramadol — Small molecule.