Fluconazole vs Hydrochlorothiazide

Fluconazole vs Hydrochlorothiazide: Overview

This comparison examines the pharmacological differences between Fluconazole and Hydrochlorothiazide.

Mechanism of Action

Fluconazole: Inhibits fungal CYP51 (lanosterol 14-alpha-demethylase).

Hydrochlorothiazide: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

Pharmacokinetics

Half-life: Fluconazole — 30 hours; Hydrochlorothiazide — 6-15 hours.

Chemical Properties

Molecular Formula: Fluconazole — C13H12F2N6O; Hydrochlorothiazide — C7H8ClN3O4S2.

Molecular Weight: Fluconazole — 306.2710 g/mol; Hydrochlorothiazide — 297.7400 g/mol.

Type: Fluconazole — Small molecule; Hydrochlorothiazide — Small molecule.