Fluconazole vs Loratadine

Fluconazole vs Loratadine: Overview

This comparison examines the pharmacological differences between Fluconazole and Loratadine.

Mechanism of Action

Fluconazole: Inhibits fungal CYP51 (lanosterol 14-alpha-demethylase).

Loratadine: Second-generation H1 antihistamine with minimal CNS effects.

Pharmacokinetics

Half-life: Fluconazole — 30 hours; Loratadine — 8 hours.

Chemical Properties

Molecular Formula: Fluconazole — C13H12F2N6O; Loratadine — C22H23ClN2O2.

Molecular Weight: Fluconazole — 306.2710 g/mol; Loratadine — 382.8800 g/mol.

Type: Fluconazole — Small molecule; Loratadine — Small molecule.