Fluconazole vs Metronidazole

Fluconazole vs Metronidazole: Overview

This comparison examines the pharmacological differences between Fluconazole and Metronidazole.

Mechanism of Action

Fluconazole: Inhibits fungal CYP51 (lanosterol 14-alpha-demethylase).

Metronidazole: Forms cytotoxic free radicals that damage bacterial DNA.

Pharmacokinetics

Half-life: Fluconazole — 30 hours; Metronidazole — 8 hours.

Chemical Properties

Molecular Formula: Fluconazole — C13H12F2N6O; Metronidazole — C6H9N3O3.

Molecular Weight: Fluconazole — 306.2710 g/mol; Metronidazole — 171.1540 g/mol.

Type: Fluconazole — Small molecule; Metronidazole — Small molecule.