Fluconazole vs Vancomycin

Fluconazole vs Vancomycin: Overview

This comparison examines the pharmacological differences between Fluconazole and Vancomycin.

Mechanism of Action

Fluconazole: Inhibits fungal CYP51 (lanosterol 14-alpha-demethylase).

Vancomycin: Glycopeptide antibiotic inhibiting cell wall synthesis by binding D-Ala-D-Ala terminus of peptidoglycan precursors.

Pharmacokinetics

Half-life: Fluconazole — 30 hours; Vancomycin — 4-6 hours.

Chemical Properties

Molecular Formula: Fluconazole — C13H12F2N6O; Vancomycin — C66H75Cl2N9O24.

Molecular Weight: Fluconazole — 306.2710 g/mol; Vancomycin — 1449.2500 g/mol.

Type: Fluconazole — Small molecule; Vancomycin — Small molecule.