Furosemide vs Hydrochlorothiazide

Furosemide vs Hydrochlorothiazide: Overview

This comparison examines the pharmacological differences between Furosemide and Hydrochlorothiazide.

Mechanism of Action

Furosemide: Loop diuretic inhibiting Na-K-2Cl cotransporter.

Hydrochlorothiazide: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

Pharmacokinetics

Half-life: Furosemide — 2 hours; Hydrochlorothiazide — 6-15 hours.

Chemical Properties

Molecular Formula: Furosemide — C12H11ClN2O5S; Hydrochlorothiazide — C7H8ClN3O4S2.

Molecular Weight: Furosemide — 330.7440 g/mol; Hydrochlorothiazide — 297.7400 g/mol.

Type: Furosemide — Small molecule; Hydrochlorothiazide — Small molecule.