Gabapentin vs Phenytoin

Gabapentin vs Phenytoin: Overview

This comparison examines the pharmacological differences between Gabapentin and Phenytoin.

Mechanism of Action

Gabapentin: Binds alpha-2-delta subunit of voltage-gated calcium channels.

Phenytoin: Sodium channel blocker stabilizing inactive state.

Pharmacokinetics

Half-life: Gabapentin — 5-7 hours; Phenytoin — 22 hours.

Chemical Properties

Molecular Formula: Gabapentin — C9H17NO2; Phenytoin — C15H12N2O2.

Molecular Weight: Gabapentin — 171.2370 g/mol; Phenytoin — 252.2680 g/mol.

Type: Gabapentin — Small molecule; Phenytoin — Small molecule.