Hydrochlorothiazide vs Irbesartan

## Hydrochlorothiazide vs Irbesartan: Overview

This comparison examines the pharmacological differences between **Hydrochlorothiazide** and **Irbesartan**.

## Mechanism of Action

**Hydrochlorothiazide**: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

**Irbesartan**: Selective non-competitive angiotensin II type 1 receptor antagonist.

## Pharmacokinetics

**Half-life**: Hydrochlorothiazide — 6-15 hours; Irbesartan — 11-15 hours.

## Chemical Properties

**Molecular Formula**: Hydrochlorothiazide — C7H8ClN3O4S2; Irbesartan — C25H28N6O.

**Molecular Weight**: Hydrochlorothiazide — 297.7400 g/mol; Irbesartan — 428.5320 g/mol.

**Type**: Hydrochlorothiazide — Small molecule; Irbesartan — Small molecule.