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Hydrochlorothiazide vs Lisinopril

Hydrochlorothiazide vs Lisinopril: Overview

This comparison examines the pharmacological differences between Hydrochlorothiazide and Lisinopril.

Mechanism of Action

Hydrochlorothiazide: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

Lisinopril: ACE inhibitor preventing conversion of angiotensin I to angiotensin II.

Pharmacokinetics

Half-life: Hydrochlorothiazide — 6-15 hours; Lisinopril — 12 hours.

Chemical Properties

Molecular Formula: Hydrochlorothiazide — C7H8ClN3O4S2; Lisinopril — C21H31N3O5.

Molecular Weight: Hydrochlorothiazide — 297.7400 g/mol; Lisinopril — 405.4900 g/mol.

Type: Hydrochlorothiazide — Small molecule; Lisinopril — Small molecule.