Hydrochlorothiazide vs Lovastatin

Hydrochlorothiazide vs Lovastatin: Overview

This comparison examines the pharmacological differences between Hydrochlorothiazide and Lovastatin.

Mechanism of Action

Hydrochlorothiazide: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

Lovastatin: First naturally derived statin; prodrug hydrolyzed to active beta-hydroxy acid inhibiting HMG-CoA reductase.

Pharmacokinetics

Half-life: Hydrochlorothiazide — 6-15 hours; Lovastatin — 2-3 hours.

Chemical Properties

Molecular Formula: Hydrochlorothiazide — C7H8ClN3O4S2; Lovastatin — C24H36O5.

Molecular Weight: Hydrochlorothiazide — 297.7400 g/mol; Lovastatin — 404.5390 g/mol.

Type: Hydrochlorothiazide — Small molecule; Lovastatin — Small molecule.