Hydrochlorothiazide vs Metoprolol

## Hydrochlorothiazide vs Metoprolol: Overview

This comparison examines the pharmacological differences between **Hydrochlorothiazide** and **Metoprolol**.

## Mechanism of Action

**Hydrochlorothiazide**: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

**Metoprolol**: Selective beta-1 adrenergic receptor blocker.

## Pharmacokinetics

**Half-life**: Hydrochlorothiazide — 6-15 hours; Metoprolol — 3-7 hours.

## Chemical Properties

**Molecular Formula**: Hydrochlorothiazide — C7H8ClN3O4S2; Metoprolol — C15H25NO3.

**Molecular Weight**: Hydrochlorothiazide — 297.7400 g/mol; Metoprolol — 267.3640 g/mol.

**Type**: Hydrochlorothiazide — Small molecule; Metoprolol — Small molecule.