Hydrochlorothiazide vs Metronidazole

Hydrochlorothiazide vs Metronidazole: Overview

This comparison examines the pharmacological differences between Hydrochlorothiazide and Metronidazole.

Mechanism of Action

Hydrochlorothiazide: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

Metronidazole: Forms cytotoxic free radicals that damage bacterial DNA.

Pharmacokinetics

Half-life: Hydrochlorothiazide — 6-15 hours; Metronidazole — 8 hours.

Chemical Properties

Molecular Formula: Hydrochlorothiazide — C7H8ClN3O4S2; Metronidazole — C6H9N3O3.

Molecular Weight: Hydrochlorothiazide — 297.7400 g/mol; Metronidazole — 171.1540 g/mol.

Type: Hydrochlorothiazide — Small molecule; Metronidazole — Small molecule.