Hydrochlorothiazide vs Ramipril

Hydrochlorothiazide vs Ramipril: Overview

This comparison examines the pharmacological differences between Hydrochlorothiazide and Ramipril.

Mechanism of Action

Hydrochlorothiazide: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

Ramipril: Prodrug converted to ramiprilat; ACE inhibitor.

Pharmacokinetics

Half-life: Hydrochlorothiazide — 6-15 hours; Ramipril — 13-17 hours.

Chemical Properties

Molecular Formula: Hydrochlorothiazide — C7H8ClN3O4S2; Ramipril — C23H32N2O5.

Molecular Weight: Hydrochlorothiazide — 297.7400 g/mol; Ramipril — 416.5120 g/mol.

Type: Hydrochlorothiazide — Small molecule; Ramipril — Small molecule.