Hydrochlorothiazide vs Sildenafil

## Hydrochlorothiazide vs Sildenafil: Overview

This comparison examines the pharmacological differences between **Hydrochlorothiazide** and **Sildenafil**.

## Mechanism of Action

**Hydrochlorothiazide**: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

**Sildenafil**: Selective PDE5 inhibitor increasing cGMP.

## Pharmacokinetics

**Half-life**: Hydrochlorothiazide — 6-15 hours; Sildenafil — 4 hours.

## Chemical Properties

**Molecular Formula**: Hydrochlorothiazide — C7H8ClN3O4S2; Sildenafil — C22H30N6O4S.

**Molecular Weight**: Hydrochlorothiazide — 297.7400 g/mol; Sildenafil — 474.5800 g/mol.

**Type**: Hydrochlorothiazide — Small molecule; Sildenafil — Small molecule.