Methylprednisolone vs Tofacitinib

## Methylprednisolone vs Tofacitinib: Overview

This comparison examines the pharmacological differences between **Methylprednisolone** and **Tofacitinib**.

## Mechanism of Action

**Methylprednisolone**: Intermediate-acting synthetic glucocorticoid.

**Tofacitinib**: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

## Pharmacokinetics

**Half-life**: Methylprednisolone — 18-36 hours; Tofacitinib — 3.2 hours.

## Chemical Properties

**Molecular Formula**: Methylprednisolone — C22H30O5; Tofacitinib — C16H20N6O.

**Molecular Weight**: Methylprednisolone — 374.4710 g/mol; Tofacitinib — 312.3700 g/mol.

**Type**: Methylprednisolone — Small molecule; Tofacitinib — Small molecule.