Nitroglycerin vs Sildenafil

## Nitroglycerin vs Sildenafil: Overview

This comparison examines the pharmacological differences between **Nitroglycerin** and **Sildenafil**.

## Mechanism of Action

**Nitroglycerin**: Nitric oxide donor causing venous and arterial vasodilation.

**Sildenafil**: Selective PDE5 inhibitor increasing cGMP.

## Pharmacokinetics

**Half-life**: Nitroglycerin — 1-4 minutes; Sildenafil — 4 hours.

## Chemical Properties

**Molecular Formula**: Nitroglycerin — C3H5N3O9; Sildenafil — C22H30N6O4S.

**Molecular Weight**: Nitroglycerin — 227.0870 g/mol; Sildenafil — 474.5800 g/mol.

**Type**: Nitroglycerin — Small molecule; Sildenafil — Small molecule.