Simvastatin vs Tofacitinib

## Simvastatin vs Tofacitinib: Overview

This comparison examines the pharmacological differences between **Simvastatin** and **Tofacitinib**.

## Mechanism of Action

**Simvastatin**: Prodrug converted to active form that inhibits HMG-CoA reductase.

**Tofacitinib**: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

## Pharmacokinetics

**Half-life**: Simvastatin — 2 hours; Tofacitinib — 3.2 hours.

## Chemical Properties

**Molecular Formula**: Simvastatin — C25H38O5; Tofacitinib — C16H20N6O.

**Molecular Weight**: Simvastatin — 418.5700 g/mol; Tofacitinib — 312.3700 g/mol.

**Type**: Simvastatin — Small molecule; Tofacitinib — Small molecule.