Trimethoprim vs Vancomycin

## Trimethoprim vs Vancomycin: Overview

This comparison examines the pharmacological differences between **Trimethoprim** and **Vancomycin**.

## Mechanism of Action

**Trimethoprim**: Dihydrofolate reductase inhibitor (bacterial selective).

**Vancomycin**: Glycopeptide antibiotic inhibiting cell wall synthesis by binding D-Ala-D-Ala terminus of peptidoglycan precursors.

## Pharmacokinetics

**Half-life**: Trimethoprim — 8-10 hours; Vancomycin — 4-6 hours.

## Chemical Properties

**Molecular Formula**: Trimethoprim — C14H18N4O3; Vancomycin — C66H75Cl2N9O24.

**Molecular Weight**: Trimethoprim — 290.3180 g/mol; Vancomycin — 1449.2500 g/mol.

**Type**: Trimethoprim — Small molecule; Vancomycin — Small molecule.