Buprenorphine vs Hydromorphone

Buprenorphine vs Hydromorphone: Overview

This comparison examines the pharmacological differences between Buprenorphine and Hydromorphone.

Mechanism of Action

Buprenorphine: Partial mu-opioid receptor agonist and kappa antagonist with high receptor affinity.

Hydromorphone: Semisynthetic mu-opioid receptor agonist approximately 5 times more potent than morphine.

Pharmacokinetics

Half-life: Buprenorphine — 24-42 hours; Hydromorphone — 2-3 hours.

Chemical Properties

Molecular Formula: Buprenorphine — C29H41NO4; Hydromorphone — C17H19NO3.

Molecular Weight: Buprenorphine — 467.6430 g/mol; Hydromorphone — 285.3380 g/mol.

Type: Buprenorphine — Small molecule; Hydromorphone — Small molecule.