Captopril vs Lovastatin

Captopril vs Lovastatin: Overview

This comparison examines the pharmacological differences between Captopril and Lovastatin.

Mechanism of Action

Captopril: First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

Lovastatin: First naturally derived statin; prodrug hydrolyzed to active beta-hydroxy acid inhibiting HMG-CoA reductase.

Pharmacokinetics

Half-life: Captopril — 1.9 hours; Lovastatin — 2-3 hours.

Chemical Properties

Molecular Formula: Captopril — C9H15NO3S; Lovastatin — C24H36O5.

Molecular Weight: Captopril — 217.2850 g/mol; Lovastatin — 404.5390 g/mol.

Type: Captopril — Small molecule; Lovastatin — Small molecule.