Captopril vs Sildenafil

Captopril vs Sildenafil: Overview

This comparison examines the pharmacological differences between Captopril and Sildenafil.

Mechanism of Action

Captopril: First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

Sildenafil: Selective PDE5 inhibitor increasing cGMP.

Pharmacokinetics

Half-life: Captopril — 1.9 hours; Sildenafil — 4 hours.

Chemical Properties

Molecular Formula: Captopril — C9H15NO3S; Sildenafil — C22H30N6O4S.

Molecular Weight: Captopril — 217.2850 g/mol; Sildenafil — 474.5800 g/mol.

Type: Captopril — Small molecule; Sildenafil — Small molecule.