Captopril vs Spironolactone

## Captopril vs Spironolactone: Overview

This comparison examines the pharmacological differences between **Captopril** and **Spironolactone**.

## Mechanism of Action

**Captopril**: First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

**Spironolactone**: Mineralocorticoid receptor antagonist.

## Pharmacokinetics

**Half-life**: Captopril — 1.9 hours; Spironolactone — 1.4 hours.

## Chemical Properties

**Molecular Formula**: Captopril — C9H15NO3S; Spironolactone — C24H32O4S.

**Molecular Weight**: Captopril — 217.2850 g/mol; Spironolactone — 416.5740 g/mol.

**Type**: Captopril — Small molecule; Spironolactone — Small molecule.