Captopril vs Valsartan

Captopril vs Valsartan: Overview

This comparison examines the pharmacological differences between Captopril and Valsartan.

Mechanism of Action

Captopril: First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

Valsartan: Angiotensin II type 1 receptor blocker.

Pharmacokinetics

Half-life: Captopril — 1.9 hours; Valsartan — 6 hours.

Chemical Properties

Molecular Formula: Captopril — C9H15NO3S; Valsartan — C24H29N5O3.

Molecular Weight: Captopril — 217.2850 g/mol; Valsartan — 435.5190 g/mol.

Type: Captopril — Small molecule; Valsartan — Small molecule.