Cetirizine vs Diphenhydramine

Cetirizine vs Diphenhydramine: Overview

This comparison examines the pharmacological differences between Cetirizine and Diphenhydramine.

Mechanism of Action

Cetirizine: Second-generation H1 antihistamine.

Diphenhydramine: First-generation H1 antihistamine with anticholinergic properties.

Pharmacokinetics

Half-life: Cetirizine — 6.5-10 hours; Diphenhydramine — 2-8 hours.

Chemical Properties

Molecular Formula: Cetirizine — C21H25ClN2O3; Diphenhydramine — C17H21NO.

Molecular Weight: Cetirizine — 388.8900 g/mol; Diphenhydramine — 255.3550 g/mol.

Type: Cetirizine — Small molecule; Diphenhydramine — Small molecule.